Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells

• Main Authors: Nicole Schäfer (Author), Hannah N. Wolf (Author), Anne Enzbrenner (Author), Juliane Schikora (Author), Maria Reichenthaler (Author), Volker Enzmann (Author), Diana Pauly (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD). The AMD pathogenesis includes both increased oxidative stress and...