Differential Effects of Oleuropein and Hydroxytyrosol on Aggregation and Stability of CFTR NBD1-ΔF508 Domain

• Main Authors: Christopher S. Robinson (Author), Jennifer A. Wyderko (Author), Yeng Vang (Author), Galen Martin (Author), Robert T. Youker (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2021-08-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Cystic Fibrosis (CF) is caused by loss of function mutations in the Cystic Fibrosis transmembrane conductance regulator (CFTR). The folding and assembly of CFTR is inefficient. Deletion of F508 in the first nucleotide binding domain (NBD1-ΔF508) further disrupts protein stability leading to endoplas...