CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study

• Egile Nagusiak: Katja S. Just (Egilea), Harald Dormann (Egilea), Mathias Freitag (Egilea), Marlen Schurig (Egilea), Miriam Böhme (Egilea), Michael Steffens (Egilea), Catharina Scholl (Egilea), Thomas Seufferlein (Egilea), Ingo Graeff (Egilea), Matthias Schwab (Egilea), Julia C. Stingl (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Cytochrome P450 (CYP) 2D6 is a polymorphic enzyme expressed in the central nervous system (CNS), important in drug metabolism and with a potentially constitutive role in CNS function such as vigilance. This study aimed to analyze variability in CYP2D6 activity linked to vigilance-related adverse dru...