Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis

• Main Authors: Tracy A. Brennan (Author), Kevin P. Egan (Author), Carter M. Lindborg (Author), Qijun Chen (Author), Mariya T. Sweetwyne (Author), Kurt D. Hankenson (Author), Sharon X. Xie (Author), Frederick B. Johnson (Author), Robert J. Pignolo (Author)
• Format: Book
• Published: The Company of Biologists, 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A major medical challenge in the elderly is osteoporosis and the high risk of fracture. Telomere dysfunction is a cause of cellular senescence and telomere shortening, which occurs with age in cells from most human tissues, including bone. Telomere defects contribute to the pathogenesis of two proge...