A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone

• Main Authors: Laure Thibaudeau (Author), Anna V. Taubenberger (Author), Boris M. Holzapfel (Author), Verena M. Quent (Author), Tobias Fuehrmann (Author), Parisa Hesami (Author), Toby D. Brown (Author), Paul D. Dalton (Author), Carl A. Power (Author), Brett G. Hollier (Author), Dietmar W. Hutmacher (Author)
• Format: Book
• Published: The Company of Biologists, 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The skeleton is a preferred homing site for breast cancer metastasis. To date, treatment options for patients with bone metastases are mostly palliative and the disease is still incurable. Indeed, key mechanisms involved in breast cancer osteotropism are still only partially understood due to the la...