Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach

• Main Authors: Keting Li (Author), Wenshu Hu (Author), Yingjie Wang (Author), Wenxing Chen (Author), Hongmei Wen (Author), Jian Liu (Author), Wei Li (Author), Bo Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractDisruption of p53-MDM2/MDMX interaction by smaller inhibitors is a promising therapeutic intervention gaining tremendous interest. However, no MDM2/MDMX inhibitors have been marketed so far. Drug repurposing is a validated, practical approach to drug discovery. In this regard, we employed st...