Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein

• Main Authors: Dongrong Yi (Author), Quanjie Li (Author), Han Wang (Author), Kai Lv (Author), Ling Ma (Author), Yujia Wang (Author), Jing Wang (Author), Yongxin Zhang (Author), Mingliang Liu (Author), Xiaoyu Li (Author), Jianxun Qi (Author), Yi Shi (Author), George F. Gao (Author), Shan Cen (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ebola virus (EBOV) infection leads to staggeringly high mortality rate. Effective and low-cost treatments are urgently needed to control frequent EBOV outbreaks in Africa. In this study, we report that a natural compound called berbamine hydrochloride strongly inhibits EBOV replication in vitro and...