Pharmacokinetic drug-drug interactions of JBPOS0101 mediated by cytochrome P450 3A4 and UDP‐glucuronosyltransferases

Abstract JBPOS0101 is a new antiepileptic drug and is a substrate of UDP‐glucuronosyltransferases (UGTs) in in vitro test. In vitro experiments showed different results regarding whether JBPOS0101 induces (EC50 136 μM) or inhibits (IC50 95.4-386.5 μM) cytochrome P450 (CYP) 3A4. As co‐medication of J...

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Main Authors: Sejung Hwang (Author), Yong Moon Choi (Author), Myoung‐Seok Kim (Author), SeungHwan Lee (Author)
Format: Book
Published: Wiley, 2024-07-01T00:00:00Z.
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