Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

• Auteurs principaux: Line Skute Bråten (Auteur), Magnus Ingelman‐Sundberg (Auteur), Marin M. Jukic (Auteur), Espen Molden (Auteur), Marianne Kristiansen Kringen (Auteur)
• Format: Livre
• Publié: Wiley, 2022-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly...