Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

• Main Authors: Line Skute Bråten (Author), Magnus Ingelman‐Sundberg (Author), Marin M. Jukic (Author), Espen Molden (Author), Marianne Kristiansen Kringen (Author)
• פורמט: ספר
• יצא לאור: Wiley, 2022-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly...