Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

• मुख्य लेखकों: Line Skute Bråten (लेखक), Magnus Ingelman‐Sundberg (लेखक), Marin M. Jukic (लेखक), Espen Molden (लेखक), Marianne Kristiansen Kringen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2022-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants. In the current study we have examined the role of a newly...