IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein

• Main Authors: Yujing Wu (Author), Aijun Zhang (Author), Wensheng Chen (Author), Qianling Xin (Author), Wenwen Pan (Author), Xiaoxi Hu (Author), Tao Li (Author), Hengshi Chen (Author), Jing Zhang (Author), Chengxin Luan (Author), Jian Ge (Author), Wei Wei (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T-cell acute lymphoblastic leukemia (T-ALL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy. Excessive IgD may play a role in T cell activation via IgD Fc receptor (FcδR). Here we aimed to investigate the effects o...