Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

• Hlavní autoři: Aida Varela-Moreira (Autor), Demian van Straten (Autor), Heleen F. van Leur (Autor), Ruud W.J. Ruiter (Autor), Anil K. Deshantri (Autor), Wim E. Hennink (Autor), Marcel H.A.M. Fens (Autor), Richard W.J. Groen (Autor), Raymond M. Schiffelers (Autor)
• Médium: Kniha
• Vydáno: Elsevier, 2020-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Carfilzomib-loaded polymeric micelles (CFZ-PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared with the aim to improve the maximum tolerated dose of carfilzomib in a "humanized" bone marrow-like scaffold model. For this, CFZ-PM w...