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Polymeric micelles loaded with carfilzomib increase tolerability in a humanized bone marrow-like scaffold mouse model

Carfilzomib-loaded polymeric micelles (CFZ-PM) based on poly(ethylene glycol)-b-poly(N-2-benzoyloxypropyl methacrylamide) (mPEG-b-p(HPMA-Bz)) were prepared with the aim to improve the maximum tolerated dose of carfilzomib in a "humanized" bone marrow-like scaffold model. For this, CFZ-PM w...

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Main Authors: Aida Varela-Moreira (Author), Demian van Straten (Author), Heleen F. van Leur (Author), Ruud W.J. Ruiter (Author), Anil K. Deshantri (Author), Wim E. Hennink (Author), Marcel H.A.M. Fens (Author), Richard W.J. Groen (Author), Raymond M. Schiffelers (Author)
Format: Book
Published: Elsevier, 2020-12-01T00:00:00Z.
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