Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells

• Main Authors: Yan-Nv Qu (Author), Li Zhang (Author), Ting Wang (Author), He-Yang Zhang (Author), Ze-Ji Yang (Author), Fang-Fang Yuan (Author), Yan Wang (Author), Si-Wei Li (Author), Xiao-Xia Jiang (Author), Xiao-Hua Xie (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aging is a predominant risk factor for many chronic conditions. Stem cell dysfunction plays a pivotal role in the aging process. Prelamin A, an abnormal processed form of the nuclear lamina protein lamin A, has been reported to trigger premature senescence. However, the mechanism driving stem cell d...