The Potential of Topoisomerase Inhibitor-Based Antibody-Drug Conjugates

• Main Authors: Seungmin Han (Author), Kwang Suk Lim (Author), Brody J. Blackburn (Author), Jina Yun (Author), Charles W. Putnam (Author), David A. Bull (Author), Young-Wook Won (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA topoisomerases are essential enzymes that stabilize DNA supercoiling and resolve entanglements. Topoisomerase inhibitors have been widely used as anti-cancer drugs for the past 20 years. Due to their selectivity as topoisomerase I (TOP1) inhibitors that trap TOP1 cleavage complexes, camptothecin...