cGMP Inhibits GTP Cyclohydrolase I Activity and Biosynthesis of Tetrahydrobiopterin in Human Umbilical Vein Endothelial Cells

• Main Authors: Hiroaki Shiraishi (Author), Taiya Kato (Author), Koji Atsuta (Author), Chiho Sumi-Ichinose (Author), Masatsugu Ohtsuki (Author), Mitsuyasu Itoh (Author), Hitoshi Hishida (Author), Shin Tada (Author), Yasuhiro Udagawa (Author), Toshiharu Nagatsu (Author), Yasumichi Hagino (Author), Hiroshi Ichinose (Author), Takahide Nomura (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: Tetrahydrobiopterin (BH4) acts as an essential cofactor for the enzymatic activity of nitric oxide (NO) synthases. Biosynthesis of the cofactor BH4 starts from GTP and requires 3 enzymatic steps, which include GTP cyclohydrolase I (GCH I) catalysis of the first and rate-limiting step. In t...