Protective effects of tadalafil on damaged podocytes in an adriamycin-induced nephrotic syndrome model

• Main Authors: Natsumi Tomita (Author), Yuji Hotta (Author), Aya Naiki-Ito (Author), Akimasa Sanagawa (Author), Tomoya Kataoka (Author), Yoko Furukawa-Hibi (Author), Satoru Takahashi (Author), Kazunori Kimura (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Podocyte injury is responsible for nephrotic syndrome. Previously, we found that tadalafil, a phosphodiesterase 5 inhibitor, might have protective effects on podocytes. Here, we investigated the effects of tadalafil in a nephrotic syndrome model and human podocyte cells.We divided adriamycin (ADR)-i...