Modification of the Linker Amino Acid in the Cell-Penetrating Peptide NickFect55 Leads to Enhanced pDNA Transfection for In Vivo Applications

• Asıl Yazarlar: Heleri H. Härk (Yazar), Ly Porosk (Yazar), Lucas R. de Mello (Yazar), Piret Arukuusk (Yazar), Emerson R. da Silva (Yazar), Kaido Kurrikoff (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2023-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors. We have previously shown that designing a "kinked" structure in the...