Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

• Main Authors: Yuxi Wang (Author), Jian Gao (Author), Song Zhao (Author), Yan Song (Author), Han Huang (Author), Guiwang Zhu (Author), Peili Jiao (Author), Xiangqing Xu (Author), Guisen Zhang (Author), Kewei Wang (Author), Liangren Zhang (Author), Zhenming Liu (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic acid and benzoic acid derivatives were identi...