Endospanin1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling

• Main Authors: Virginie Vauthier (Author), Clara Roujeau (Author), Patty Chen (Author), Chamsy Sarkis (Author), Stéphanie Migrenne (Author), Toru Hosoi (Author), Koichiro Ozawa (Author), Yves Rouillé (Author), Marc Foretz (Author), Jacques Mallet (Author), Jean-Marie Launay (Author), Christophe Magnan (Author), Ralf Jockers (Author), Julie Dam (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The hypothalamic arcuate nucleus (ARC) is a major integration center for energy and glucose homeostasis that responds to leptin. Resistance to leptin in the ARC is an important component of the development of obesity and type 2 diabetes. Recently, we showed that Endospanin1 (Endo1) is a negative reg...