Single-cell analysis reveals the COL11A1+ fibroblasts are cancer-specific fibroblasts that promote tumor progression

• Main Authors: Jiayu Zhang (Author), Shiqi Lu (Author), Tong Lu (Author), Donghui Han (Author), Keying Zhang (Author), Lunbiao Gan (Author), Xinjie Wu (Author), Yu Li (Author), Xiaolong Zhao (Author), Zhengxuan Li (Author), Yajie Shen (Author), Sijun Hu (Author), Fa Yang (Author), Weihong Wen (Author), Weijun Qin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Cancer-associated fibroblasts (CAFs) promote tumor progression through extracellular matrix (ECM) remodeling and extensive communication with other cells in tumor microenvironment. However, most CAF-targeting strategies failed in clinical trials due to the heterogeneity of CAFs. Hence, w...