Epithelial Dual Oxidase 2 Shapes the Mucosal Microbiome and Contributes to Inflammatory Susceptibility

• Egile Nagusiak: Juan Camilo Castrillón-Betancur (Egilea), Víctor Alonso López-Agudelo (Egilea), Nina Sommer (Egilea), Sven Cleeves (Egilea), Joana Pimenta Bernardes (Egilea), Saskia Weber-Stiehl (Egilea), Philip Rosenstiel (Egilea), Felix Sommer (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Reactive oxygen species (ROS) are highly reactive molecules formed from diatomic oxygen. They act as cellular signals, exert antibiotic activity towards invading microorganisms, but can also damage host cells. Dual oxidase 2 (DUOX2) is the main ROS-producing enzyme in the intestine, regulated by cue...