Linking metabolism and histone acetylation dynamics by integrated metabolic flux analysis of Acetyl-CoA and histone acetylation sites

• Main Authors: Anna-Sophia Egger (Author), Eva Rauch (Author), Suraj Sharma (Author), Tobias Kipura (Author), Madlen Hotze (Author), Thomas Mair (Author), Alina Hohenegg (Author), Philipp Kobler (Author), Ines Heiland (Author), Marcel Kwiatkowski (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Histone acetylation is an important epigenetic modification that regulates various biological processes and cell homeostasis. Acetyl-CoA, a hub molecule of metabolism, is the substrate for histone acetylation, thus linking metabolism with epigenetic regulation. However, still relatively...