Physiologically‐based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate

• Main Authors: Nashid Farhan (Author), Rodrigo Cristofoletti (Author), Sumit Basu (Author), Sarah Kim (Author), Karthik Lingineni (Author), Sibo Jiang (Author), Joshua D. Brown (Author), Lanyan (Lucy) (Author), Lawrence J. Lesko (Author), Stephan Schmidt (Author)
• Format: Book
• Published: Wiley, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The exposure‐response relationship of direct acting oral anti‐coagulants (DOACs) for bleeding risk is steep relative to ischemic stroke reduction. As a result, small changes in exposure may lead to bleeding events. The overall goal of this project was to determine the effect of critical for...