Physiologically‐based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate

• Главные авторы: Nashid Farhan (Автор), Rodrigo Cristofoletti (Автор), Sumit Basu (Автор), Sarah Kim (Автор), Karthik Lingineni (Автор), Sibo Jiang (Автор), Joshua D. Brown (Автор), Lanyan (Lucy) (Автор), Lawrence J. Lesko (Автор), Stephan Schmidt (Автор)
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• Опубликовано: Wiley, 2021-03-01T00:00:00Z.
• Предметы: article
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Abstract The exposure‐response relationship of direct acting oral anti‐coagulants (DOACs) for bleeding risk is steep relative to ischemic stroke reduction. As a result, small changes in exposure may lead to bleeding events. The overall goal of this project was to determine the effect of critical for...