RAB18 regulates extrahepatic siRNA-mediated gene silencing efficacy

• Main Authors: Jiamiao Lu (Author), Jasper Lee (Author), Eric Yuan (Author), Devin L. Wakefield (Author), Matt Kanke (Author), Danielle Pruitt (Author), Jose Barreda (Author), Ingrid C. Rulifson (Author), Jiansong Xie (Author), John Ferbas (Author), Jason Long (Author), Bryan Meade (Author), Oliver Homann (Author), Wei Guo (Author), Tina Gomes (Author), Hong Zhou (Author), Bin Wu (Author), Jixin Cui (Author), Songli Wang (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small interfering RNAs (siRNAs) hold considerable therapeutic potential to selectively silence previously "undruggable" disease-associated targets, offering new opportunities to fight human diseases. This therapeutic strategy, however, is limited by the inability of naked siRNAs to passive...