Regulation of macrophage cell surface GAPDH alters LL-37 internalization and downstream effects in the cell

• Main Authors: Asmita Dhiman (Author), Sharmila Talukdar (Author), Gaurav Kumar Chaubey (Author), Rahul Dilawari (Author), Radheshyam Modanwal (Author), Surbhi Chaudhary (Author), Anil Patidar (Author), Vishant Mahendra Boradia (Author), Pradeep Kumbhar (Author), Chaaya Iyengar Raje (Author), Manoj Raje (Author)
• Format: Book
• Published: Karger Publishers, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycobacterium tuberculosis (M.tb), the major causative agent of tuberculosis (TB), has evolved mechanisms to evade host defenses and persist within host cells. Host directed therapies (HDTs) against infected cells are emerging as an effective option. Cationic host defense peptide LL-37 is known to i...