Enhanced blood-brain barrier penetration and glioma therapy mediated by T7 peptide-modified low-density lipoprotein particles

• Main Authors: Meng Liang (Author), Chunhong Gao (Author), Yuli Wang (Author), Wei Gong (Author), Shiyao Fu (Author), Lin Cui (Author), Zhenhan Zhou (Author), Xiaoyang Chu (Author), Yue Zhang (Author), Qianqian Liu (Author), Xiong Zhao (Author), Baoquan Zhao (Author), Meiyan Yang (Author), Zhiping Li (Author), Chunrong Yang (Author), Xiangyang Xie (Author), Yang Yang (Author), Chunsheng Gao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic outcome for the treatment of glioma was often limited due to the non-targeted nature and low permeability of drugs across the blood-brain barrier (BBB). An ideal glioma-targeted delivery system need to traverse the BBB and then target glioma cells with adequate optimized physiochemical p...