iPSC-cardiomyocytes in the preclinical prediction of candidate pharmaceutical toxicity

• मुख्य लेखकों: Tim Y. T. Lee (लेखक), John G. Coles (लेखक), Jason T. Maynes (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Many challenges remain in the preclinical evaluation, adjudication, and prioritization of novel compounds in therapeutic discovery pipelines. These obstacles are evident by the large number of candidate or lead compounds failing to reach clinical trials, significantly due to a lack of efficacy in th...