Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain

• Main Authors: Elphick Maurice R (Author), Barrett David (Author), Eldeeb Khalil (Author), Jhaveri Maulik (Author), Richardson Denise (Author), Guasti Leonardo (Author), Alexander Stephen PH (Author), Kendall David (Author), Michael Gregory J (Author), Chapman Victoria (Author)
• Format: Book
• Published: SAGE Publishing, 2009-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Activation of spinal microglia contributes to aberrant pain responses associated with neuropathic pain states. Endocannabinoids (ECs) are present in the spinal cord, and inhibit nociceptive processing; levels of ECs may be altered by microglia which modulate the...