Safety and tolerability of a single dose T0001 in Chinese healthy adult volunteers: a first-in-human ascending dose study

• Main Authors: Tan Zhang (Author), Minjie Zhang (Author), Li'an Zu (Author), Qian Wang (Author), Qi Wang (Author), Wei Wang (Author), Yitong Wang (Author), Yannan Zang (Author), Zhenwei Xie (Author), Shi Chen (Author), Mei Wang (Author), Qingshan Zheng (Author), Zhanguo Li (Author), Guihong Chen (Author), Yi Fang (Author)
• Format: Book
• Published: Universidade de São Paulo, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T0001 is the first mutant of etanercept with a higher affinity to tumor necrosis factor α (TNF-α) than etanercept. In order to investigate the safety and tolerability of T0001, a study was carried out in healthy Chinese subjects. A first-in-human, dose escalation study was conducted in healthy Chine...