Mitochondrial H₂O₂ Is a Central Mediator of Diclofenac-Induced Hepatocellular Injury

• Main Authors: Sin Ri Kim (Author), Ji Won Park (Author), You-Jin Choi (Author), Seong Keun Sonn (Author), Goo Taeg Oh (Author), Byung-Hoon Lee (Author), Tong-Shin Chang (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonsteroidal anti-inflammatory drug (NSAID) use is associated with adverse consequences, including hepatic injury. The detrimental hepatotoxicity of diclofenac, a widely used NSAID, is primarily connected to oxidative damage in mitochondria, which are the primary source of reactive oxygen species (R...