Inhibition of the α-carbonic anhydrase from Vibrio cholerae with amides and sulfonamides incorporating imidazole moieties

• Main Authors: Daniela De Vita (Author), Andrea Angeli (Author), Fabiana Pandolfi (Author), Martina Bortolami (Author), Roberta Costi (Author), Roberto Di Santo (Author), Elisabetta Suffredini (Author), Mariangela Ceruso (Author), Sonia Del Prete (Author), Clemente Capasso (Author), Luigi Scipione (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We discovered novel and selective sulfonamides/amides acting as inhibitors of the α-carbonic anhydrase (CA, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae (VchCA). This Gram-negative bacterium is the causative agent of cholera and colonises the upper small intestine where sodium bicarbona...