Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents

• Main Authors: Wenjie Xue (Author), Yaling Wang (Author), Xu Lian (Author), Xueyao Li (Author), Jing Pang (Author), Johannes Kirchmair (Author), Kebin Wu (Author), Zunsheng Han (Author), Xuefu You (Author), Hongmin Zhang (Author), Jie Xia (Author), Song Wu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Emerging drug resistance is generating an urgent need for novel and effective antibiotics. A promising target that has not yet been addressed by approved antibiotics is the bacterial DNA gyrase subunit B (GyrB), and GyrB inhibitors could be effective against drug-resistant bacteria, such as methicil...