Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights

• Main Authors: Wagdy M. Eldehna (Author), Raed M. Maklad (Author), Hadia Almahli (Author), Tarfah Al-Warhi (Author), Eslam B. Elkaeed (Author), Mohammed A. S. Abourehab (Author), Hatem A. Abdel-Aziz (Author), Ahmed M. El Kerdawy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the current work, a hybridisation strategy was adopted between the privileged building blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors. The hybrid structures were linked to different aromatic semicarbazide, thiosemicarbazide, or acylhydrazone tails to an...