Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4

• Egile Nagusiak: Alexander Lukasz (Egilea), Jan Beneke (Egilea), Kristina Thamm (Egilea), Jan T. Kielstein (Egilea), Jan Menne (Egilea), Jan-Henrik Mikesch (Egilea), Bernhard M. W. Schmidt (Egilea), Hermann Haller (Egilea), Philipp Kümpers (Egilea), Sascha David (Egilea), Mario Schiffer (Egilea)
• Formatua: Liburua
• Argitaratua: Hindawi Limited, 2015-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Escherichia coli O104:H4-associated hemolytic uremic syndrome (HUS) is characterized by Shiga toxin-induced vascular damage. As indicated by recent studies, dysregulation of the angiopoietin (Angpt)/Tie2 ligand receptor system may be crucial for endothelial dysfunction in HUS. Early Angpt-2 levels q...