Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4

• Main Authors: Alexander Lukasz (Author), Jan Beneke (Author), Kristina Thamm (Author), Jan T. Kielstein (Author), Jan Menne (Author), Jan-Henrik Mikesch (Author), Bernhard M. W. Schmidt (Author), Hermann Haller (Author), Philipp Kümpers (Author), Sascha David (Author), Mario Schiffer (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Escherichia coli O104:H4-associated hemolytic uremic syndrome (HUS) is characterized by Shiga toxin-induced vascular damage. As indicated by recent studies, dysregulation of the angiopoietin (Angpt)/Tie2 ligand receptor system may be crucial for endothelial dysfunction in HUS. Early Angpt-2 levels q...