Multiparameter ranking of carbazoles for anti-trypanosome lead discovery

• Main Authors: Amrita Sharma (Author), Carlos E. Sanz-Rodriguez (Author), Michael P. Pollastri (Author), Andrei Purmal (Author), Kojo Mensa-Wilmot (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The criteria for the progression of hits in the discovery of leads for human African trypanosomiasis (HAT), a neglected disease caused by the microbial eukaryote Trypanosoma brucei, are not standardized. Hits are advanced upon meeting thresholds for drug-like molecules. Following those principles, p...