Multiparameter ranking of carbazoles for anti-trypanosome lead discovery

• Váldodahkkit: Amrita Sharma (Dahkki), Carlos E. Sanz-Rodriguez (Dahkki), Michael P. Pollastri (Dahkki), Andrei Purmal (Dahkki), Kojo Mensa-Wilmot (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The criteria for the progression of hits in the discovery of leads for human African trypanosomiasis (HAT), a neglected disease caused by the microbial eukaryote Trypanosoma brucei, are not standardized. Hits are advanced upon meeting thresholds for drug-like molecules. Following those principles, p...