Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction

• Main Authors: Rui Huang (Author), Lijun Zhang (Author), Jinmei Jin (Author), Yudong Zhou (Author), Hongwei Zhang (Author), Chao Lv (Author), Dong Lu (Author), Ye Wu (Author), Hong Zhang (Author), Sanhong Liu (Author), Hongzhuan Chen (Author), Xin Luan (Author), Weidong Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths, characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1α (HIF-1α) is a major regulator involved in cellular response to changes of oxygen levels, supporting the adaptation of tumor cells...