A tutorial for model‐based evaluation and translation of cardiovascular safety in preclinical trials

• Main Authors: Victoria Kulesh (Author), Igor Vasyutin (Author), Alina Volkova (Author), Kirill Peskov (Author), Holly Kimko (Author), Victor Sokolov (Author), Ravindra Alluri (Author)
• Format: Book
• Published: Wiley, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Assessment of drug‐induced effects on the cardiovascular (CV) system remains a critical component of the drug discovery process enabling refinement of the therapeutic index. Predicting potential drug‐related unintended CV effects in the preclinical stage is necessary for first‐in‐human dose...