Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor‐derived breast cancer cells

• Main Authors: Caterina Collodet (Author), Kelly Blust (Author), Savvini Gkouma (Author), Emmy Ståhl (Author), Xinsong Chen (Author), Johan Hartman (Author), My Hedhammar (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Traditional cancer models rely on 2D cell cultures or 3D spheroids, which fail to recapitulate cell‐extracellular matrix (ECM) interactions, a key element of tumor development. Existing hydrogel‐based 3D alternatives lack mechanical support for cell growth and often suffer from low reproduc...