Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach

• Main Authors: Elisa Nuti (Author), Valeria La Pietra (Author), Simona Daniele (Author), Doretta Cuffaro (Author), Lidia Ciccone (Author), Chiara Giacomelli (Author), Carolina Cason (Author), Alfonso Carotenuto (Author), Vincenzo Maria D'Amore (Author), Eleonora Da Pozzo (Author), Barbara Costa (Author), Riccardo Di Leo (Author), Manola Comar (Author), Luciana Marinelli (Author), Claudia Martini (Author), Armando Rossello (Author)
• Format: Bog
• Udgivet: MDPI AG, 2022-10-01T00:00:00Z.
• Fag: article
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Intracellular pathogens, such as <i>Chlamydia trachomatis</i>, have been recently shown to induce degradation of p53 during infection, thus impairing the protective response of the host cells. Therefore, p53 reactivation by disruption of the p53-MDM2 complex could reduce infection and re...