Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine

Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine

Background: There is limited information on the safety or efficacy of currently recommended antimalarial drugs in patients with sickle cell disease (SCD), a population predisposed to worse outcomes if affected by acute malaria. Artesunate-amodiaquine (ASAQ) is the first-line treatment for uncomplica...

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Main Authors: George O. Adjei, MD, PhD (Author), Seth K. Amponsah, PhD (Author), Bamenla Q. Goka, MB. ChB, MRCP, FWACP (Author), Christabel Enweronu-Laryea, MBBS, MSc, FRCPCH (Author), Lorna Renner, MB. ChB, MPH, FRCPCH, FGCPS (Author), Abdul Malik Sulley, MSc (Author), Michael Alifrangis, MSc, PhD (Author), Jorgen A.L. Kurtzhals, MD, PhD (Author)
Format: Book
Published: Elsevier, 2019-01-01T00:00:00Z.
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