Investigation of the Possible Allostery of Koumine Extracted From Gelsemium elegans Benth. And Analgesic Mechanism Associated With Neurosteroids

• Main Authors: Bojun Xiong (Author), Wenbing You (Author), Yufei Luo (Author), Guilin Jin (Author), Minxia Wu (Author), Ying Xu (Author), Jian Yang (Author), Huihui Huang (Author), Changxi Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Translocator protein 18 kDa (TSPO) is an evolutionarily conserved 5-transmembrane domain protein, and has been considered as an important therapeutic target for the treatment of pain. We have recently reported the in vitro and in vivo pharmacological characterization of koumine as a TSPO positive al...