A Fully Human Monoclonal Antibody Targeting cKIT Is a Potent Inhibitor of Pathological Choroidal Neovascularization in Mice

• Main Authors: Songyi Seo (Author), Koung Li Kim (Author), Yeongju Yeo (Author), Ryul-I Kim (Author), Hayoung Jeong (Author), Jin-Ock Kim (Author), Sun-Hwa Song (Author), Mi-Jin An (Author), Jung-Woong Kim (Author), Hye Kyoung Hong (Author), Min Hee Ham (Author), Se Joon Woo (Author), Jong-Hyuk Sung (Author), Sang Gyu Park (Author), Wonhee Suh (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stem cell factor (SCF) and its receptor, cKIT, are novel regulators of pathological neovascularization in the eye, which suggests that inhibition of SCF/cKIT signaling may be a novel pharmacological strategy for treating neovascular age-related macular degeneration (AMD). This study evaluated the th...