Identification of new small molecules as dual FoxM1 and Hsp70 inhibitors using computational methods

• Main Authors: Zahra Alimardan (Author), Maryam Abbasi (Author), Ghadamali Khodarahmi (Author), Khosrow Kashfi (Author), Farshid Hasanzadeh (Author), Aghaei Mahmud (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: FoxM1 and Hsp70 proteins are highly expressed in many cancers. Thus, their inhibition serves as Bonafede targets in cancer treatment. Experimental approach: FDI-6, an inhibitor of FoxM1, was selected as a template, and based on its structure, a new library from the ZINC datab...