Ivabradine Treatment Reduces Cardiomyocyte Apoptosis in a Murine Model of Chronic Viral Myocarditis

• Main Authors: Ge Li-Sha (Author), Liu Li (Author), Zhou De-Pu (Author), Shi Zhe-Wei (Author), Gu Xiaohong (Author), Chen Guang-Yi (Author), Li Jia (Author), Lin Jia-Feng (Author), Chu Maoping (Author), Li Yue-Chun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study was designed to explore the effects of ivabradine on cardiomyocyte apoptosis in a murine model of chronic viral myocarditis (CVMC). Mice were inoculated intraperitoneally with Coxsackievirus B3 at days 1, 14, and 28, respectively. On day 42, the mice were gavaged with ivabradine for 30 da...