Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer's disease?

• मुख्य लेखकों: Filomena Lo Vecchio (लेखक), Paola Bisceglia (लेखक), Bruno Pietro Imbimbo (लेखक), Madia Lozupone (लेखक), Raffaela Rita Latino (लेखक), Emanuela Resta (लेखक), Maurizio Leone (लेखक), Vincenzo Solfrizzi (लेखक), Antonio Greco (लेखक), Antonio Daniele (लेखक), Mark Watling (लेखक), Francesco Panza (लेखक), Davide Seripa (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: SAGE Publishing, 2022-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Human apolipoprotein E (ApoE) is a 299-amino acid secreted glycoprotein that binds cholesterol and phospholipids. ApoE exists as three common isoforms (ApoE2, ApoE3, and ApoE4) and heterozygous carriers of the ε4 allele of the gene encoding ApoE ( APOE ) have a fourfold greater risk of developing Al...