Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer's disease?

• Main Authors: Filomena Lo Vecchio (Author), Paola Bisceglia (Author), Bruno Pietro Imbimbo (Author), Madia Lozupone (Author), Raffaela Rita Latino (Author), Emanuela Resta (Author), Maurizio Leone (Author), Vincenzo Solfrizzi (Author), Antonio Greco (Author), Antonio Daniele (Author), Mark Watling (Author), Francesco Panza (Author), Davide Seripa (Author)
• Format: Book
• Published: SAGE Publishing, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human apolipoprotein E (ApoE) is a 299-amino acid secreted glycoprotein that binds cholesterol and phospholipids. ApoE exists as three common isoforms (ApoE2, ApoE3, and ApoE4) and heterozygous carriers of the ε4 allele of the gene encoding ApoE ( APOE ) have a fourfold greater risk of developing Al...