Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study

• Main Authors: Tomoyoshi Miyamoto (Author), Shiori Hiramoto (Author), Ayano Kanto (Author), Maho Tsubota (Author), Masanori Fujitani (Author), Hiroki Fukuyama (Author), Shigekatsu Hatanaka (Author), Fumiko Sekiguchi (Author), Yuichi Koizumi (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We performed clinical retrospective study in female cancer patients and fundamental experiments in mice, in order to clarify risk factors for paclitaxel-induced peripheral neuropathy (PIPN). In the clinical study, 131 of 189 female outpatients with cancer undergoing paclitaxel-based chemotherapy met...