Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study

• Hoofdauteurs: Tomoyoshi Miyamoto (Auteur), Shiori Hiramoto (Auteur), Ayano Kanto (Auteur), Maho Tsubota (Auteur), Masanori Fujitani (Auteur), Hiroki Fukuyama (Auteur), Shigekatsu Hatanaka (Auteur), Fumiko Sekiguchi (Auteur), Yuichi Koizumi (Auteur), Atsufumi Kawabata (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2021-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

We performed clinical retrospective study in female cancer patients and fundamental experiments in mice, in order to clarify risk factors for paclitaxel-induced peripheral neuropathy (PIPN). In the clinical study, 131 of 189 female outpatients with cancer undergoing paclitaxel-based chemotherapy met...