Antibody blockade of CD96 by distinct molecular mechanisms

• Main Authors: Peter S. Lee (Author), Bryant Chau (Author), Ishita Barman (Author), Christine Bee (Author), Aarti Jashnani (Author), Jason M. Hogan (Author), Barbara Aguilar (Author), Gavin Dollinger (Author), Arvind Rajpal (Author), Pavel Strop (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The molecular interactions of mouse CD96 to CD155 ligand and to two surrogate antibodies have been investigated. Biophysical and structural studies demonstrate that CD96 forms a homodimer but assembles as 1:1 heterodimeric complexes with CD155 or with one of the surrogate antibodies, which compete f...