Preclinical assessment of the treatment of second-stage African trypanosomiasis with cordycepin and deoxycoformycin.

• Main Authors: Suman K Vodnala (Author), Marcela Ferella (Author), Hilda Lundén-Miguel (Author), Evans Betha (Author), Nick van Reet (Author), Daniel Ndem Amin (Author), Bo Oberg (Author), Björn Andersson (Author), Krister Kristensson (Author), Hans Wigzell (Author), Martin E Rottenberg (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: There is an urgent need to substitute the highly toxic compounds still in use for treatment of the encephalitic stage of human African trypanosomiasis (HAT). We here assessed the treatment with the doublet cordycepin and the deaminase inhibitor deoxycoformycin for this stage of infection...